Publications by authors named "K J Schimmel"
Article Synopsis
- Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder that leads to abnormal blood vessel formations, particularly in the skin and internal organs, due to mutations in one of three specific genes.
- Research indicates that these vascular malformations result from a two-hit mutation mechanism, where a primary genetic mutation is compounded by additional events such as somatic mutations or loss of heterozygosity.
- The study confirms that both skin and internal organ abnormalities share similar molecular processes, emphasizing that losing function in both copies of the HHT gene is essential for developing these vascular issues.
Background: Pathogenic concepts of right ventricular (RV) failure in pulmonary arterial hypertension focus on a critical loss of microvasculature. However, the methods underpinning prior studies did not take into account the 3-dimensional (3D) aspects of cardiac tissue, making accurate quantification difficult. We applied deep-tissue imaging to the pressure-overloaded RV to uncover the 3D properties of the microvascular network and determine whether deficient microvascular adaptation contributes to RV failure.
View Article and Find Full Text PDFThe laboratory rat emerges as a useful tool for studying the interaction between the host and its microbiome. To advance principles relevant to the human microbiome, we systematically investigated and defined the multitissue microbial biogeography of healthy Fischer 344 rats across their lifespan. Microbial community profiling data were extracted and integrated with host transcriptomic data from the Sequencing Quality Control consortium.
View Article and Find Full Text PDFThe laboratory rat emerges as a useful tool for studying the interaction between the host and its microbiome. To advance principles relevant to the human microbiome, we systematically investigated and defined a multi-tissue full lifespan microbial biogeography for healthy Fischer 344 rats. Microbial community profiling data was extracted and integrated with host transcriptomic data from the Sequencing Quality Control (SEQC) consortium.
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