Low and high frequency isometric handgrip exercise training similarly reduce resting blood pressure in young normotensive adults: A randomised controlled trial.

We investigated the effects of low and high frequency isometric handgrip exercise training (IHGT) on resting blood pressure, and the affective/perceptual responses during training. Sixty young normotensive adults were randomised to either a no-intervention control group (CON:  = 20; 12 female) or a group performing either two (LOW:  = 20; 18 female) or four (HIGH:  = 20; 13 female) sessions/week of IHGT for 4 weeks. IHGT involved 4 × 2-min holds at 30% maximal voluntary contraction using the dominant hand.

HED LANG - A Hierarchical Event Descriptors library extension for annotation of language cognition experiments.

Experimental design in language cognition research often involves presenting language material while measuring associated behavior and/or neural activity. To make the collected data easily and fully analyzable by both the original data authors and others, it is important to have detailed information about the stimulus presentation events, including the nature and properties of the presented stimuli, using a common vocabulary and syntax. We present HED LANG, a library extension of the Hierarchical Event Descriptors (HED) event annotation schema for time series behavioral and neuroimaging data.

Medical and Surgical Episodes Among Hospital Participants in the Bundled Payments for Care Improvement-Advanced Program.

Importance: Hospital participation in the Bundled Payments for Care Improvement-Advanced (BPCI-A) initiative has been associated with modest savings and stable clinical outcomes overall, but it is unknown whether the program performs differently for medical and surgical or procedural (henceforth, surgical) episodes.

Objective: To assess the association of BPCI-A participation with Medicare spending and clinical outcomes for medical and surgical episodes.

Design, Setting, And Participants: This retrospective difference-in-differences cohort study utilized 100% Medicare fee-for-service inpatient claims for episodes initiated between January 1, 2017, and September 30, 2019, and included 90 days of follow-up.

Cerebrospinal Fluid and Serum Neuron-Specific Enolase in Niemann-Pick Disease Type C1.

Niemann-Pick disease, type C1 (NPC1) is an ultra rare, autosomal recessive disorder characterized by impaired intracellular cholesterol trafficking. This study assessed neuron-specific enolase (NSE) as a biomarker for disease status and treatment response in individuals with NPC1. We also evaluated the concordance between serum and cerebrospinal fluid (CSF) NSE measurements.

Evolutionary Signatures of The Erosion of Sexual Reproduction Genes in Domesticated Cassava (Manihot esculenta).

Centuries of clonal propagation in cassava (Manihot esculenta) have reduced sexual recombination, leading to the accumulation of deleterious mutations. This has resulted in both inbreeding depression affecting yield and a significant decrease in reproductive performance, creating hurdles for contemporary breeding programs. Cassava is a member of the Euphorbiaceae family, including notable species such as rubber tree (Hevea brasiliensis) and poinsettia (Euphorbia pulcherrima).