Publications by authors named "K J Reagan"
Background: Before the discovery of effective antiviral drugs, feline infectious peritonitis (FIP) was a uniformly fatal disease of cats. Multiple antiviral treatments have been recognized, but optimization of treatment protocols is needed.
Objective: To evaluate the efficacy of PO molnupiravir (MPV; EIDD-2801) to treat effusive FIP.
Antibiotic treatment promotes the outgrowth of intestinal Candida albicans, but the mechanisms driving this fungal bloom remain incompletely understood. We identify oxygen as a resource required for post-antibiotic C. albicans expansion.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create a machine learning model to diagnose portosystemic shunts (PSS) in dogs using normal demographic and clinicopathologic data, addressing the limitations of current diagnostic tests.
- The machine learning models developed included one to predict whether a dog has PSS and another to categorize the type of PSS, achieving high accuracy rates (94.3% sensitivity for PSS detection and 85.7% accuracy for subtype classification).
- These models can serve as effective screening tools to help veterinarians decide when to proceed with more advanced diagnostic techniques.
In the original publication [...
View Article and Find Full Text PDFFeline infectious peritonitis (FIP) is a multisystemic, generally lethal immuno-inflammatory disease of domestic cats caused by an infection with a genetic variant of feline coronavirus, referred to as the FIP virus (FIPV). We leveraged data from four different antiviral clinical trials performed at the University of California, Davis. Collectively, a total of 60 client-owned domestic cats, each with a confirmed diagnosis of naturally occurring FIP, were treated with a variety of antiviral compounds.
View Article and Find Full Text PDF