Publications by authors named "K J Philip"
Emerging Therapy: Extracorporeal Shockwave Therapy for Musculoskeletal Conditions.
Am J Phys Med Rehabil
January 2025
Article Synopsis
- Bullous emphysema is a chronic lung disease marked by the presence of large air spaces called bullae, with giant bullae being particularly significant and often requiring surgical removal known as bullectomy.
- A 35-year-old man with a history of COVID-19 experienced chest pain and difficulty breathing, leading to the discovery of a giant bulla in his left lung on imaging scans.
- Remarkably, after monitoring over several months, the giant bulla spontaneously resolved without surgery, suggesting that infectious processes may play a role in this phenomenon, highlighting the importance of careful imaging and follow-up in similar cases.
Rising blast-percentage or secondary (s) AML transformation (sAML) in MPNs leads to JAK inhibitor (JAKi) therapy-resistance and poor survival. Here, we demonstrate that the CDK7 inhibitor (CDK7i) SY-5609 treatment depletes phenotypically-characterized post-MPN-sAML stem/progenitor cells. In the cultured post-MPN sAML SET2 and HEL as well as patient-derived (PD) post-MPN-sAML cells, SY-5609 treatment inhibited growth and induced lethality, while sparing normal cells.
View Article and Find Full Text PDFBackground: Negative perceptions of psilocybin and challenges of participant enrollment may represent barriers to conducting a randomized controlled trial examining psilocybin for chronic neuropathic pain.
Aim: Prior to trial initiation, we aimed to examine patient attitudes toward the trial via a prospective preference assessment.
Methods: Twenty-six patients with chronic neuropathic pain participated in a prospective preference assessment comprising quantitative (survey) and qualitative (interview) components.