Publications by authors named "K J Mutton"
Objectives: Many patients with meningitis have no aetiology identified leading to unnecessary antimicrobials and prolonged hospitalisation. We used viral capture sequencing to identify possible pathogenic viruses in adults with community-acquired meningitis.
Methods: Cerebrospinal fluid (CSF) from 73 patients was tested by VirCapSeq-VERT, a probe set designed to capture viral targets using high throughput sequencing.
Background: Viral meningitis is increasingly recognised, but little is known about the frequency with which it occurs, or the causes and outcomes in the UK. We aimed to determine the incidence, causes, and sequelae in UK adults to improve the management of patients and assist in health service planning.
Methods: We did a multicentre prospective observational cohort study of adults with suspected meningitis at 42 hospitals across England.
Introduction: Outbreaks linked to cosmetic piercing are rare, but can cause significant illness. We report the investigation and management of a point-source outbreak that occurred during a Black Friday promotional event in North West England.
Methods: Outbreak investigation was led by Public Health England, and included active case finding among individuals pierced at a piercing premises between 25/11/2016 (Black Friday) and 7/12/2016.
Article Synopsis
- This study investigated how common the fungus Pneumocystis jirovecii is in adults with cystic fibrosis during periods of clinical stability vs. acute lung flare-ups.
- Researchers analyzed sputum samples for the presence of P. jirovecii DNA from patients at the Manchester Adult Cystic Fibrosis Centre, distinguishing between stable conditions and exacerbations using specific scoring methods.
- Results showed P. jirovecii was more frequently found during acute exacerbations (about 9.2%) compared to stable conditions (about 2%), and it was rarely detected in patients who had taken a specific antibiotic (co-trimoxazole) recently.
A previously fit and well man developed acute respiratory failure due to environmental mould exposure from living in damp rental accommodation. Despite aggressive intensive care management he rapidly deteriorated and required respiratory and cardiac Extracorporeal Membrane Oxygenation. We hypothesize that poor domiciliary conditions may make an underestimated contribution to community respiratory disease.
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