Publications by authors named "K J Milne"
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View Article and Find Full Text PDFBACKGROUNDDespite an overall poor prognosis, about 15% of patients with advanced-stage tubo-ovarian high-grade serous carcinoma (HGSC) survive 10 or more years after standard treatment.METHODSWe evaluated the tumor microenvironment of this exceptional, understudied group using a large international cohort enriched for long-term survivors (LTS; 10+ years; n = 374) compared with mid-term (MTS; 5-7.99 years; n = 433) and short-term survivors (STS; 2-4.
View Article and Find Full Text PDFArticle Synopsis
- Low-grade serous ovarian carcinoma (LGSC) is a rare and dangerous type of ovarian cancer that is different from the more common high-grade version.
- Researchers studied tissue samples from LGSC, high-grade serous ovarian carcinoma (HGSC), and serous borderline tumors (SBTs) to understand how they differ.
- They found that the environment around the tumors was different in LGSC, including specific proteins and immune cells, which suggests that changing this environment could help develop new treatments.