Publications by authors named "K J Lindley"
Aims: Polyethylene glycol (PEG) is used in many applications including drug development. Due to exposure to environmental products, there is a high prevalence of preexisting anti-PEG antibodies in the global human population. The presence of anti-PEG antibodies is a concern for potentially reducing the efficacy of therapeutics after administration and represents a risk of safety events after exposure to PEGylated drug products.
View Article and Find Full Text PDFOptimal Approaches for Pregnant Patients Undergoing Percutaneous Coronary Intervention.
Interv Cardiol Clin
January 2025
Cardiovascular disease is the leading cause of maternal mortality in the United States. Pregnancy is associated with increased risk of acute myocardial infarction (AMI) and outcomes of pregnancy-associated AMI (PAMI) are poor. Spontaneous coronary artery dissection is the most common cause of PAMI.
View Article and Find Full Text PDFArticle Synopsis
- Congenital diarrhoeas and enteropathies (CODE) are a diverse set of disorders that can cause severe dehydration in infants shortly after birth, with varying clinical symptoms.
- Advances in genetic testing and management, particularly with intravenous nutrition, have significantly improved survival rates for affected individuals into adulthood.
- The review emphasizes the need for greater awareness and understanding of CODE among healthcare professionals, and notes the necessity for further research to identify new subtypes and develop effective therapies.
Article Synopsis
- Cardiac arrhythmias are a major concern in pregnant individuals, contributing significantly to cardiovascular disease during this time.
- Anesthesiologists must be well-versed in recognizing and managing these arrhythmias, as their incidence is on the rise in pregnancy.
- The article explores common arrhythmias, their risk factors, diagnosis, management strategies, peripartum monitoring, and recommendations for labor analgesia, along with advanced interventions like cardioversion and support for cardiac devices.
Obstetric anesthesia management of dilated cardiomyopathies and heart failure: a narrative review.
Int J Obstet Anesth
November 2024
Pregnancy in patients with dilated cardiomyopathy carries a significantly increased risk of maternal mortality or severe morbidity, and pregnancy is typically considered contraindicated for patients with severely reduced ventricular function. Nonetheless, anesthesiologists will still encounter patients with cardiomyopathy requiring delivery or termination care. This review describes how NT-ProBNP testing and echocardiography can help with early recognition of heart failure in pregnancy, and describes a suggested approach to anesthetic management of patients with cardiomyopathies or acute heart failure, including hemodynamic goals, use of vasoactive medications and mechanical support.
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