Publications by authors named "K J Lennartz"
Differentiation of hematopoietic stem cells is regulated by a concert of different transcription factors. Disturbed transcription factor function can be the basis of (pre)malignancies such as myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Growth factor independence 1b (Gfi1b) is a repressing transcription factor regulating quiescence of hematopoietic stem cells and differentiation of erythrocytes and platelets.
View Article and Find Full Text PDFPurpose: The therapy of unresectable advanced thyroid carcinomas shows unfavorable outcome. Constitutive nuclear factor-κB (NF-κB) activation in thyroid carcinomas frequently contributes to therapeutic resistance; the radioiodine therapy often fails due to the loss of differentiated functions in advanced thyroid carcinomas. Curcumin is known for its anticancer properties in a series of cancers, but only few studies have focused on thyroid cancer.
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- Malignant cells grow not just from their own factors, but also from the environment around them, especially cells like monocytes and macrophages.
- In acute myeloid leukemia, certain macrophages help the cancer grow instead of fighting it, and their presence in the body is linked to how long mice survive in experiments.
- A specific protein called Growth factor independence 1 is important because it affects how these macrophages change; without it, they are less likely to support the cancer.
Genetic and epigenetic aberrations contribute to the initiation and progression of acute myeloid leukemia (AML). GFI1, a zinc-finger transcriptional repressor, exerts its function by recruiting histone deacetylases to target genes. We present data that low expression of GFI1 is associated with an inferior prognosis of AML patients.
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