The dead salmon strikes again: Reports of unconscious processing in the hippocampus may reflect Type-I error.

Steinkrauss and Slotnick (2024) reviewed neuroimaging studies linking the hippocampus with implicit memory. They conclude that there is no convincing evidence that the hippocampus is associated with implicit memory because prior studies are confounded by explicit memory (among other factors). Here, we ask a different yet equally important question: do reports of unconscious hippocampal activity reflect a Type-I error (i.

The power, potential, benefits, and challenges of implementing high-throughput sequencing in food safety systems.

The development and application of modern sequencing technologies have led to many new improvements in food safety and public health. With unprecedented resolution and big data, high-throughput sequencing (HTS) has enabled food safety specialists to sequence marker genes, whole genomes, and transcriptomes of microorganisms almost in real-time. These data reveal not only the identity of a pathogen or an organism of interest in the food supply but its virulence potential and functional characteristics.

Genetic screen for suppressors of increased silencing in rpd3 mutants in Saccharomyces cerevisiae identifies a potential role for H3K4 methylation.

Several studies have identified the paradoxical phenotype of increased heterochromatic gene silencing at specific loci that results from deletion or mutation of the histone deacetylase (HDAC) gene RPD3. To further understand this phenomenon, we conducted a genetic screen for suppressors of this extended silencing phenotype at the HMR locus in Saccharomyces cerevisiae. Most of the mutations that suppressed extended HMR silencing in rpd3 mutants without completely abolishing silencing were identified in the histone H3 lysine 4 methylation (H3K4me) pathway, specifically in SET1, BRE1, and BRE2.

Co-Producing Interdisciplinary Knowledge and Action for Sustainable Water Governance: Lessons from the Development of a Water Resources Decision Support System in Pernambuco, Brazil.

One of the most pressing global challenges for sustainable development is freshwater management. Sustainable water governance requires interdisciplinary knowledge about environmental and social processes as well as participatory strategies that bring scientists, managers, policymakers, and other stakeholders together to cooperatively produce knowledge and solutions, promote social learning, and build enduring institutional capacity. Cooperative production of knowledge and action is designed to enhance the likelihood that the findings, models, simulations, and decision support tools developed are scientifically credible, solutions-oriented, and relevant to management needs and stakeholders' perspectives.

Improvement in Patient-Specific Outcomes After Carpal Tunnel Release in Patients Older Than 80 Years.

Outcomes after carpal tunnel release (CTR) may be influenced by age, disease chronicity, and disease severity. Multiple studies report mixed results between age and improvement through a validated instrument, the Brigham and Women's Carpal Tunnel Questionnaire (BWQ). However, these investigations did not control for confounders and had small cohorts of younger patients.