Publications by authors named "K J Lafaro"
Unlabelled: Pancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis, in part resulting from cellular heterogeneity that supports overall tumorigenicity. Cancer associated fibroblasts (CAF) are key determinants of PDAC biology and response to systemic therapy. While CAF subtypes have been defined, the effects of patient-specific CAF heterogeneity and plasticity on tumor cell behavior remain unclear.
View Article and Find Full Text PDFASO Visual Abstract: Defining and Predicting Early Recurrence for Optimal Treatment Strategies in Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer--An International Multicenter Study.
Joseph R Habib Ammar A Javed Ingmar F Rompen Camila Hidalgo Salinas Anthony Sorrentino Kelly J Lafaro
Ann Surg Oncol
January 2025
Defining and Predicting Early Recurrence for Optimal Treatment Strategies for Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: An International Multicenter Study.
Joseph R Habib Ammar A Javed Ingmar F Rompen Camila Hidalgo Salinas Anthony Sorrentino Kelly J Lafaro
Ann Surg Oncol
December 2024
Article Synopsis
- This study investigates early recurrence in patients with pancreatic ductal adenocarcinoma (PDAC) derived from intraductal papillary mucinous neoplasm (IPMN), aiming to identify predictors to help guide patient management.
- The research found that early recurrence is defined as occurring within 10.5 months post-surgery, affecting 38% of patients who experienced recurrence, with CA19-9 levels and N2 disease being significant predictors.
- Adjuvant chemotherapy showed a survival advantage only for high-risk patients, highlighting the importance of risk stratification for better treatment outcomes.
Current Endoscopic and Surgical Management of Pancreatic Cystic Lesions: A Comprehensive Review.
Turk J Gastroenterol
November 2024
Article Synopsis
- Pancreatic cystic lesions (PCLs) are commonly found during medical imaging, with their occurrence increasing as people age, making accurate identification of their type and cancer risk vital for treatment.
- Advanced endoscopic techniques, such as ultrasound and biopsy methods, allow for more precise diagnosis and management of PCLs, guiding clinicians on whether to monitor or operate.
- This review aims to summarize existing research on the endoscopic and surgical approaches to PCLs, examining their advantages, challenges, and future developments to assist healthcare professionals in their decision-making process.
Article Synopsis
- The study focuses on pancreatic acinar cell carcinoma (pACC), a rare type of pancreatic cancer, highlighting its clinical characteristics, genetic mutations, and patient survival outcomes.
- A total of 61 patients who underwent surgery between 1999 and 2022 were analyzed, showing a median overall survival of 73 months and a recurrence-free survival of 22 months; those with oligometastatic disease had even better outcomes.
- Significant genetic findings included mutations in core genes related to DNA repair pathways in 26% of patients, indicating potential avenues for targeted treatment.