Publications by authors named "K J Ivey"
Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the effects of non-nutritive sweeteners (NNS) on glucose absorption and gut microbiota in mice, revealing that NNS increases glucose absorption without relying on gut microbiota.
- - Mice given antibiotics to reduce gut microbiota showed improved glucose tolerance, suggesting that gut bacteria play an important role in glycemic responses.
- - Results indicate that while NNS enhances glucose absorption, it does not negatively affect glycemic responses, and gut microbiota depletion positively impacts glucose tolerance through the activity of GLP-1.
Background: Dietary quality plays an important role in disease development and prognosis, and diet is also a key contributor to disparities in many chronic diseases and health conditions.
Objectives: This study aimed to assess racial and ethnic disparities experienced by veterans; we examined food intake and dietary quality across different racial and ethnic groups of United States veterans.
Methods: The study included 420,730 males and females aged 19-107 y (91.
Article Synopsis
- The study focused on understanding how various environmental factors contribute to the risk of colorectal cancer (CRC) and aimed to enhance screening methods by recalibrating an environmental risk score (e-Score) among U.S. Veterans.
- Data was collected from over 227,000 male participants from the Million Veteran Program, with significant relationships found between CRC risk and factors like age, education, lifestyle, and medication use.
- The new e-Score model outperformed the original one in predicting CRC risk, suggesting it could improve personalized screening and prevention efforts for colorectal cancer among veterans.
Article Synopsis
- High antibiotic prescriptions in aged care could lead to increased antibiotic-resistant pathogens in residents, raising concerns about treatment failures.
- A study analyzed stool samples from 164 residents in South Australia, linking antibiotic use over the past year to the presence and quantity of antibiotic resistance genes (ARGs).
- Findings revealed that over 1100 unique ARGs were identified, with doxycycline being a major risk factor for high ARG levels, particularly influencing resistance to penicillins and cephalosporins, highlighting the need for cautious antibiotic use in this population.