Biomarkers.

Background: Reactive astrogliosis refers to functional and morphological changes in astrocytes that occur with neuronal damage in numerous neurological conditions. PET tracers targeting monoamine oxidase B (MAO-B) are used to visualize reactive astrogliosis in the living brain. [F]SMBT-1, a MAO-B selective PET tracer, was developed by modifying the chemical structure of [F]THK5351.

Biomarkers.

Background: In daily clinical practice, we often encounter cases with atypical symptoms and imaging findings, even among those diagnosed with Alzheimer's disease. Amyloid PET and cerebrospinal fluid examinations were performed in such non-typical cases and young cases.

Method: A total of 85 patients underwent both amyloid PET and cerebrospinal fluid examinations.

Biomarkers.

Background: The method of obtaining pseudo-cerebral blood flow images from the initial minutes of amyloid PET scans has been proposed. This technique proves to be highly valuable as it not only indicates the presence of amyloid accumulation but also reveals sites of neurodegeneration. However, the obtained early images represent the K1 image rather than cerebral blood flow.

Alzheimer's Imaging Consortium.

Background: Despite the clinical importance and significant social burden of neuropsychiatric symptoms (NPS) in dementia, the underlying neurobiological mechanism remains poorly understood. Recently, neuroimaging-derived brain-age estimation by machine-learning analysis has shown promise as an individual-level biomarker. We investigated the relationship between NPS and brain-age in amnestic mild cognitive impairment (MCI) and early dementia.

Alzheimer's Imaging Consortium.

Background: Reactive astrogliosis refers to functional and morphological changes in astrocytes that occur with neuronal damage in numerous neurological conditions. PET tracers targeting monoamine oxidase B (MAO-B) are used to visualize reactive astrogliosis in the living brain. [18F]SMBT-1, a MAO-B selective PET tracer, was developed by modifying the chemical structure of [18F]THK5351.