Publications by authors named "K J Hutchinson"
Background: Indirect calorimetry is the gold standard field-testing technique for measuring energy expenditure and exercise intensity based on the volume of oxygen consumed (VO, mL O/min). Although heart rate is often used as a proxy for VO, heart rate-based estimates of VO may be inaccurate after stroke due to changes in the heart rate-VO relationship. Our objective was to evaluate in people post stroke the accuracy of using heart rate to estimate relative walking VO (wVO) and classify exercise intensity.
View Article and Find Full Text PDFArticle Synopsis
- * In a phase 3 trial involving 325 patients, those taking inavolisib had a median progression-free survival of 15.0 months, significantly better than the 7.3 months for the placebo group, indicating better disease management.
- * The treatment with inavolisib showed promising results with a 58.4% objective response rate; however, there were notable side effects, similar between both groups, including high rates of neutropenia
Equitable access means that timely, sensitive and respectful treatment is offered to all people. Adults with disability access ED care more frequently than the general population. However, in Australia and internationally, people with disability experience poorer healthcare access and outcomes than the general population.
View Article and Find Full Text PDFArticle Synopsis
- Loss-of-function mutations in a specific gene linked to dystonia reveal similarities to idiopathic dystonia, highlighting the gene's role in regulating cAMP levels in the striatum, a brain region critical for movement.
- Researchers developed a genetic mouse model to study the effects of knocking out this gene in a targeted manner, observing significant motor impairments and dystonic behaviors in these mice.
- The findings indicate that the loss of this gene increases the excitability of certain neurons, suggesting that reducing this hyperexcitability could lead to potential treatments for both genetic and idiopathic forms of dystonia.