Publications by authors named "K J Hoffer"
Background: Research on circulating tumor cells (CTCs) offers the opportunity to better understand the initial steps of blood-borne metastasis as main cause of cancer-related deaths. Here, we have used the colon cancer CTC-MCC-41 and breast cancer CTC-ITB-01 lines, which were both established from human CTCs as permanent cell lines as models to further study CTC biology with special emphasis on anchorage-independent survival and growth.
Methods And Results: Both cell lines showed a marked intrinsic plasticity to switch between suspension and adherent in vitro growth, in 2D adherent culture conditions, and established an equilibrium of both growth patterns with predominant adherent cells in the CTC-MCC-41 line (77%) and suspension cells in the CTC-ITB-01 line (85%).
Purpose: To compare the accuracy of intraocular lens (IOL) power calculation formulas for myopic eyes requiring negative diopter powered IOLs.
Design: Retrospective case series.
Setting: K… hospital and Y… Hospital, …, ….
Objective: To describe a novel method called "three variable optimization" that entails a process of doing just one calculation to zero out the mean prediction error of an entire dataset (regardless of size), using only 3 variables: (1) the constant used, (2) the average intraocular lens (IOL) power, and (3) the average prediction error (PE as actual refraction - predicted refraction).
Design: Development, evaluation, and testing of a method to optimize personal IOL constants.
Methods: A dataset of 876 eyes was used as a training set, and another dataset of 1,079 eyes was used to test the method.
Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the threshold for activation of the autoimmunity checkpoint, allowing malignant cells with strong oncogenic B-cell receptor signaling to escape negative selection. Here, we show that SHIP1 is differentially expressed across B-ALL subtypes and that high versus low SHIP1 expression is associated with specific B-ALL subgroups. In particular, we found high SHIP1 expression in both, Philadelphia chromosome (Ph)-positive and ETV6-RUNX1-rearranged B-ALL cells.
View Article and Find Full Text PDFPurpose: To compare 2 different datasets, using Eyetemis, an online analytical tool designed for assessing the spherical equivalent prediction errors (SEQ-PEs) of intraocular lens (IOL) power calculation formulas after cataract surgery.
Setting: Institutional.
Design: Retrospective case series.