Publications by authors named "K J Flynn"
Expression, purification and characterization of a dual function α-dioxygenase/peroxidase from Mycolicibacterium smegmatis.
Biochim Biophys Acta Mol Cell Biol Lipids
December 2024
An open reading frame from the actinobacterium Mycolicibacterium smegmatis annotated as a Prostaglandin H Synthase (PGHS) was expressed with an N-terminal (his) tag and purified to homogeneity. The enzyme has a monomeric molecular weight of 68.3 kD and exists as a dimer in the presence of nonionic detergent.
View Article and Find Full Text PDFObjective: Evaluate the effect of fathers' participation in the Preemie Prep for Parents (P3) program on maternal learning and fathers' preterm birth knowledge.
Methods: Mothers with preterm birth predisposing medical condition(s) enrolled with or without the baby's father and were randomized to the P3 intervention (text-messages linking to animated videos) or control (patient education webpages). Parent Prematurity Knowledge Questionnaire assessed knowledge, including unmarried fathers' legal neonatal decision-making ability.
Article Synopsis
- Geostatistical data on drug overdose mortality is often aggregated at larger geographic levels, which can mask significant disparities in urban areas.
- This study focused on Cuyahoga County, Ohio, analyzing drug-related mortality rates at the finer census tract level, revealing that individuals in low-opportunity areas are four times more likely to experience drug-related deaths compared to those in high-opportunity areas.
- The research emphasizes the importance of detailed geographic analysis to uncover variations in drug mortality risk, suggesting that targeting specific communities can enhance public health interventions.
Introduction: Insulin-like growth factor binding protein-3 (IGFBP-3) exerts varying effects on estrogen receptor alpha (ERα)-positive and triple-negative breast cancer (TNBC) cells. In ERα-positive cells, IGFBP-3 is antiproliferative and proapoptotic. In contrast, IGFBP-3 stimulates proliferation in triple-negative breast cancer (TNBC) cells via EGFR activation.
View Article and Find Full Text PDFPurpose: Few risk factors for early adjuvant endocrine discontinuation have been identified, but clinical trials suggest pre-AET symptom burden might be important. We sought to assess this in an academic practice.
Methods: We examined baseline and up to five years of follow-up information for postmenopausal women with stage I-III hormone-receptor positive breast cancer 2014-2019 receiving oncologist prescriptions for AET.