Publications by authors named "K J Christensen"
Aim/background: Patient-reported outcome measurement instruments are important tools in understanding a breast reconstruction's impact on the patients' quality of life. A psychometric validation is essential before applying a patient-reported outcome measurement instrument in clinical practice and research. The BREAST-Q is a specific, validated questionnaire for breast surgery outcomes that has been translated from English to Danish.
View Article and Find Full Text PDFUsing whole-genome sequencing (WGS) might offer insights into rare genetic variants associated with healthy aging and extreme longevity (EL), potentially pointing to useful therapeutic targets. In this study, we conducted a genome-wide association study using WGS data from the Long Life Family Study and identified a novel longevity-associated variant rs6543176 in the SLC9A2 gene. This SNP also showed a significant association with reduced hypertension risk and an increased, though not statistically significant, cancer risk.
View Article and Find Full Text PDFBackground: Oral treatment with the exogenous ketone body 3-hydroxybutyrate improves cardiac function in patients with heart failure with reduced ejection fraction, but ketosis is limited to 3 to 4 hours. Treatment with (R)-1,3-butanediol (BD) provides prolonged ketosis in healthy controls, but the hemodynamic and metabolic profile is unexplored in patients with heart failure with reduced ejection fraction.
Methods And Results: This was a randomized, single-blind, placebo-controlled, crossover study.
Article Synopsis
- Muscular strength, particularly measured by handgrip strength (HGS), is an important indicator of health and a predictor of age-related diseases, but no international benchmarks exist for HGS across different ages and sexes.
- The study systematically analyzed data from over 2.4 million adults across 69 countries to establish sex- and age-specific norms for HGS, identifying a peak in strength between ages 30 and 39 before a gradual decline.
- Findings revealed that while absolute and body size-normalized HGS improves slightly in early adulthood, a more significant drop occurs from middle to late adulthood, with males generally experiencing a faster decline than females.