Publications by authors named "K J Beek"
Background And Purpose: Radiotherapy for paediatric posterior fossa tumours may cause complications in the brainstem and upper spinal cord due to high doses. With proton therapy (PT) this risk may increase due to higher relative biological effectiveness (RBE) from elevated linear energy transfer (LET). This study assesses variations in LET in the brainstem and spinal cord in proton treatment plans from European centres.
View Article and Find Full Text PDFBackgrounds: Post-dilatation after stenting with a non-compliant (NC) balloon can be used to improve overall percutaneous coronary intervention (PCI) result. Due to lack of evidence on the effect of post-dilatation on adverse clinical endpoints there is no consensus whether post-dilatation should be used routinely. The aim of the current study was to determine the contemporary practice of post-dilatation.
View Article and Find Full Text PDFThe quantum-mechanical nuclear-shell structure determines the stability and limits of the existence of the heaviest nuclides with large proton numbers Z ≳ 100 (refs. ). Shell effects also affect the sizes and shapes of atomic nuclei, as shown by laser spectroscopy studies in lighter nuclides.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to validate the MAGNIFI-CD index as an effective tool for monitoring treatment responses in patients with perianal fistulising Crohn's disease (pfCD).
- It analyzed data from 65 patients treated surgically or medically, showing a significant decrease in MAGNIFI-CD scores for those who responded to treatment and excellent agreement between two independent radiologists scoring the index.
- The research establishes key cut-off values for determining treatment responses, suggesting that the MAGNIFI-CD index is a reliable and responsive MRI scoring method for this condition.
Background And Purpose: As no guidelines for pencil beam scanning (PBS) proton therapy (PT) of paediatric posterior fossa (PF) tumours exist to date, this study investigated planning techniques across European PT centres, with special considerations for brainstem and spinal cord sparing.
Materials And Methods: A survey and a treatment planning comparison were initiated across nineteen European PBS-PT centres treating paediatric patients. The survey assessed all aspects of the treatment chain, including but not limited to delineations, dose constraints and treatment planning.