Publications by authors named "K J Andresen"
Background: The left atrial (LA) volume has been demonstrated to be an important predictor of adverse outcome in patients with various cardiac conditions, including acute myocardial infarction (AMI). However, new treatment strategies in patients with AMI have led to better patient outcomes. We hypothesised that increased LA size could still predict mortality in patients with AMI despite improved treatment strategies.
View Article and Find Full Text PDFBackground: Codelists are required to extract meaningful information on characteristics and events from routinely collected health data such as electronic health records. Research using routinely collected health data relies on codelists to define study populations and variables, thus, trustworthy codelists are important. Here, we provide a checklist, in the style of commonly used reporting guidelines, to help researchers adhere to best practice in codelist development and sharing.
View Article and Find Full Text PDFThe prognostic value of left atrial (LA) volume is well-established in acute myocardial infarction (AMI) patients. LA strain provides further patophysological insights. In the present study, we evaluated LA volume and LA strain in AMI patients including those with atrial fibrillation (AF).
View Article and Find Full Text PDFArticle Synopsis
- Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by movement issues and cognitive/psychiatric symptoms, caused by a mutation in the huntingtin gene leading to toxic protein accumulation.
- A clinical trial named FELL-HD is underway to test the safety and tolerability of the drug felodipine, selected for its ability to induce autophagy and degrade the mutant huntingtin protein in early HD patients.
- This phase II trial will follow 18 participants over 58 weeks, measuring adverse events and various health outcomes, and has received ethical approval and regulatory clearance for the study's conduct.