Mitochondrial Genome Instability in Yeast Cytoplasmic Hybrids.

Unlike most animals, some fungi, including baker's yeast, inherit mitochondrial DNA (mtDNA) from both parents. When haploid yeast cells fuse, they form a heteroplasmic zygote, whose offspring retain one or the other variant of mtDNA. Meanwhile, some mutant mtDNA (), with large deletions in the nucleotide sequence, can displace wild-type () mtDNA.

Tyrosol induces multiple drug resistance in yeast .

In yeast, multiple (pleiotropic) drug resistance (MDR) transporters efflux xenobiotics from the cytoplasm to the environment. Additionally, upon the accumulation of xenobiotics in the cells, MDR genes are induced. At the same time, fungal cells can produce secondary metabolites with physico-chemical properties similar to MDR transporter substrates.

Role of Dead Cells in Collective Stress Tolerance in Microbial Communities: Evidence from Yeast.

A substantial part of yeast life cycle takes place in the communities where the cells are surrounded by their own clones. Meanwhile, yeast cell fitness depends not only on its own adaptations but also on the processes in the neighboring cells. Moreover, even if a cell loses its clonogenic ability, it is still capable of protecting surrounding cells that are still alive.

Heterogeneity of Starved Yeast Cells in IF Levels Suggests the Role of This Protein .

In mitochondria, a small protein IF suppresses the hydrolytic activity of ATP synthase and presumably prevents excessive ATP hydrolysis under conditions of energy deprivation. In yeast , IF homologs are encoded by two paralogous genes: and . expression is known to aggravate the deleterious effects of mitochondrial DNA (mtDNA) depletion.

Attenuated ADP-inhibition of FF ATPase mitigates manifestations of mitochondrial dysfunction in yeast.

Proton-translocating FF ATP synthase (F-ATPase) couples ATP synthesis or hydrolysis to transmembrane proton transport in bacteria, chloroplasts, and mitochondria. The primary function of the mitochondrial FF is ATP synthesis driven by protonmotive force (pmf) generated by the respiratory chain. However, when pmf is low or absent (e.