A Novel Direct Puncture Cannulation Blood Pump Support System: in Vivo Experimental Proof of Concept for a Therapeutic Approach with Cardiac Arrest.

The rate of out-of-hospital cardiac arrest is increasing according to the changes in the proportion of ages in super-aged society. We developed a novel transcutaneous cannulation-type mechanical circulatory system for an alternative therapeutic approach to cardiac arrest using a small centrifugal blood pump. We proposed a transcutaneous mechanical circulatory support capable of rapid installation and quick start of circulatory support for recovery after cardiac arrest by left ventricular direct puncture using the Seldinger technique.

Development and Preliminary Evaluation of a Short-Term Direct Left Ventricular Puncture Type Compact Percutaneous Blood Pump.

Mechanical circulatory support (MCS) devices play a quintessential role in providing hemodynamic support to heart failure patients. The development of short-term compact percutaneous MCS devices which are ideal for emergency acute heart failure applications is one of the promising advances in MCS technologies. This study presents the design and preliminary performance evaluation of a compact percutaneous centrifugal blood pump which is potentially ideal for the quick provision of left ventricular support during emergency cardiac arrest.

A Fatal Case of Necrotizing Pneumonia Caused by Hypermucoviscous .

Necrotizing pneumonia has a high mortality rate of approximately 50%. Its computed tomography findings lack enhancement in areas of consolidation. These findings should be interpreted as potentially indicative of a severe clinical course.

Correlation Between Histopathological Response of Esophageal Squamous Cell Carcinoma to Neoadjuvant DCF Therapy and the Clinical Efficacy of Palliative Chemotherapy for Recurrence.

Background: Docetaxel-cisplatin-5-fluorouracil (DCF) is a new standard neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma (ESCC) in Japan. However, some patients experience recurrence and require further systemic platinum-containing chemotherapy. It is unclear whether such regimens are appropriate after a poor histopathological response to neoadjuvant DCF.

Treatment strategy involving docetaxel plus cisplatin and 5-fluorouracil followed by conversion surgery for locally advanced unresectable/borderline resectable esophageal squamous cell carcinoma.

Definitive chemoradiotherapy (dCRT) is the standard treatment for unresectable (T4) esophageal squamous cell carcinoma (ESCC), but the prognosis is poor. Borderline resectable (T3br) ESCC has been discussed, but its clinical features and appropriate treatment are unclear. The effects of docetaxel plus cisplatin and 5-fluorouracil (DCF) therapy and subsequent surgery for potentially unresectable ESCC remain controversial.