Publications by authors named "K Ishige"
Article Synopsis
- * An 87-year-old woman with pancreatitis experienced significant abdominal pain, and tests showed high amylase levels and severe anemia, leading to a CT scan that identified a pseudoaneurysm in her dorsal pancreatic artery.
- * Due to her age and the high risks associated with surgery, the medical team opted for a less invasive endovascular procedure, successfully embolizing the pseudoaneurysm, which was confirmed to have resolved in a follow-up CT scan a week later.
Purpose: A short period of disuse of 1-2 weeks due to factors such as illness or injury can lead to muscle atrophy, affecting both athletic performance and health. Recent research has shown that uridine 5'-monophosphate (5'-UMP) can counteract disuse-induced muscle atrophy by increasing PGC-1α expression and inhibiting atrogin-1 expression. However, the effect of 5'-UMP on disuse muscle atrophy in humans remains unknown.
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- The study aimed to evaluate the effectiveness and safety of proton beam therapy (PBT) for treating hepatocellular carcinoma (HCC) with bile duct invasion (BDI), which generally has a poor prognosis and lacks standardized treatment protocols.
- 15 patients received PBT between 2009 and 2018, with findings showing 1-, 2-, and 3-year overall survival rates of 80.0%, 58.7%, and 40.2%, indicating some level of positive outcome, though with significant toxicity risks.
- Results indicated that while PBT is feasible for managing BDIHCC with manageable side effects, it still requires careful consideration due to the occurrence of
Respiratory syncytial virus (RSV) is a leading cause of upper and lower respiratory tract infection, especially in children and the elderly. Various vaccines containing the major transmembrane surface proteins of RSV (proteins F and G) have been tested; however, they have either afforded inadequate protection or are associated with the risk of vaccine-enhanced disease (VED). Recently, F protein-based maternal immunization and vaccines for elderly patients have shown promising results in phase III clinical trials, however, these vaccines have been administered by injection.
View Article and Find Full Text PDFAtrogin-1 and muscle RING finger 1 (MuRF1) are ubiquitin ligases specifically expressed during skeletal muscle atrophy and mediate muscle protein degradation. In contrast, PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α), which is a master regulator of mitochondrial biosynthesis, protects skeletal muscle from atrophy. Pyrimidine nucleoside 5'-monophosphates, such as cytidine 5'-monophosphate (5'-CMP) and uridine 5'-monophosphate (5'-UMP), induce PGC-1α expression and promote myotube formation in mouse C2C12 cells.
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