Publications by authors named "K Imanaka-Yoshida"
Background: The effects of myocarditis after mRNA COVID-19 vaccination (mCV) on myocardial tissue, and the association between cardiomyocyte injury and clinical presentation, are not fully understood.
Methods And Results: We retrospectively registered patients clinically diagnosed with myocarditis after the first or second mCV who underwent endomyocardial biopsy or autopsy from 42 participating centers in Japan. We investigated the histological features and their association with clinical presentation based on cardiomyocyte injury.
The lung is a major dose-limiting organ for radiation therapy (RT) for cancer in the thoracic region, and the clarification of radiation-induced lung damage (RILD) is important. However, there have been few reports containing a detailed comparison of radiographic images with the pathological findings of radiation pneumonitis (RP)/radiation fibrosis (RF). We recently reported the upregulated expression of tenascin-C (TNC), an inflammation-associated extracellular matrix molecule, in surgically resected lung tissue, and elevated serum levels were elevated in a RILD patient.
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- The study aimed to see if cardiovascular magnetic resonance radiomics can differentiate between noncollagen and inflammatory extracellular space from collagen in patients with dilated cardiomyopathy.
- Researchers analyzed data from 132 patients who had undergone heart imaging and a biopsy, calculating various radiomic features and using principal component analysis to narrow them down for better diagnostic accuracy.
- Results showed four distinct histopathological groups, revealing that noncollagenous extracellular space expansion had the strongest link to myocardial inflammation, and using radiomics improved the differentiation between types of extracellular space compared to traditional imaging methods.
Article Synopsis
- Venous malformations (VMs) are the most common type of vascular malformations, primarily linked to mutations in the TEK and PIK3CA genes, which may affect the PI3K/AKT signaling pathway.
- A study of 114 patients found that 43% had TEK mutations, 11.4% had PIK3CA mutations, and 1.75% had both; TEK-mutant VMs were more prevalent in younger patients and often involved skin differently than other mutations.
- Analysis demonstrated higher levels of phosphorylated AKT in TEK-mutant VMs, and unique gene expression patterns were identified, suggesting that understanding these mutations could lead to advancements in targeted treatment approaches.