Publications by authors named "K Ilicic"
High-linear energy transfer (LET) radiation, such as heavy ions is associated with a higher relative biological effectiveness (RBE) than low-LET radiation, such as photons. Irradiation with low- and high-LET particles differ in the interaction with the cellular matter and therefore in the spatial dose distribution. When a single high-LET particle interacts with matter, it results in doses of up to thousands of gray (Gy) locally concentrated around the ion trajectory, whereas the mean dose averaged over the target, such as a cell nucleus is only in the range of a Gy.
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- - The novel Fe-Pt-YbO core-shell nanoparticles, measuring 10 nm, can effectively diffuse through neuronal tissue and can be controlled with magnetic fields for enhanced biomedical applications, including cancer treatment.
- - These nanoparticles exhibit superparamagnetic properties initially and become ferromagnetic after annealing, which improves NMRI contrast and allows for hyperthermia treatment purposes.
- - Neutron-activation of the shell leads to the incorporation of low-energy β-radiation isotopes (Yb, Lu) that, combined with their capability for optical visualization, successfully killed over 98% of human glioblastoma cells in tests, showcasing their potential in cancer therapies.
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- - Inflammatory skin reactions are common side effects of radiation therapy, which need to be addressed for better patient health care.
- - A pre-clinical study used irradiated skin models and optical coherence tomography (OCT) alongside histological staining to analyze skin changes from radiation exposure.
- - Findings revealed structural skin alterations like keratinization and thickness changes, indicating the potential for OCT to monitor early skin inflammation and radiotherapy side effects, enhancing patient care.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFProton radiotherapy using minibeams of sub-millimeter dimensions reduces side effects in comparison to conventional proton therapy due to spatial fractionation. Since the proton minibeams widen with depth, the homogeneous irradiation of a tumor can be ensured by adjusting the beam distances to tumor size and depth to maintain tumor control as in conventional proton therapy. The inherent advantages of protons in comparison to photons like a limited range that prevents a dosage of distal tissues are maintained by proton minibeams and can even be exploited for interlacing from different beam directions.
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