Publications by authors named "K Ikezoe"
Background: The composite physiologic index (CPI) was developed to estimate the extent of interstitial lung disease (ILD) in idiopathic pulmonary fibrosis (IPF) patients based on pulmonary function tests (PFTs). The CALIPER-revised version of the CPI (CALIPER-CPI) was also developed to estimate the volume fraction of ILD measured by CALIPER, an automated quantitative CT postprocessing software. Recently, artificial intelligence-based quantitative CT image analysis software (AIQCT), which can be used to quantify the bronchial volume separately from the ILD volume, was developed and validated in IPF.
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- Erdheim-Chester disease (ECD) is a rare condition involving abnormal cell growth, characterized by specific types of histiocytes and granulomas leading to tissue fibrosis.
- About 50% of ECD patients show cardiovascular issues on imaging, but detailed pathological findings are not widely reported.
- An autopsy of an ECD patient revealed a link between arterial blockages and a BRAF gene mutation, suggesting the need to investigate BRAF mutations in ECD patients with arterial complications.
Article Synopsis
- This study investigates chronic lung allograft dysfunction (CLAD) following deceased-donor and living-donor lung transplants to unveil differences in their characteristics and prognosis.
- Data from 123 deceased-donor and 67 living-donor lung transplants were analyzed, highlighting that living-donor transplants had fewer human leukocyte antigen mismatches and better outcomes in some clinical aspects.
- Although living-donor transplants had a higher occurrence of restrictive allograft syndrome, overall survival rates after transplantation and post-CLAD onset were similar between both transplant groups, with living-donor grafts showing a lower cumulative incidence of CLAD compared to deceased-donor grafts.
Background: Interstitial lung abnormalities (ILAs) on CT may affect the clinical outcomes in patients with chronic obstructive pulmonary disease (COPD), but their quantification remains unestablished. This study examined whether artificial intelligence (AI)-based segmentation could be applied to identify ILAs using two COPD cohorts.
Methods: ILAs were diagnosed visually based on the Fleischner Society definition.
A 52-year-old man had developed hearing loss since childhood, as well as recurrent foot ulcers and osteomyelitis since his forties. He presented with gait disturbance and dysarthria that had worsened over four years and a month, respectively. Neurological exams revealed cognitive impairment, proximal weakness of the lower extremities, generalized hyperrflexia, ataxia, sensory disturbances predominant in deep sensation, urinary retention, and gait instability.
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