Publications by authors named "K Iio"
Article Synopsis
- - The delta opioid receptor (DOP) is identified as a potential target for new antidepressants, as its selective agonist KNT-127 shows promise for rapid antidepressant effects while minimizing side effects.
- - In experiments, KNT-127 reduced behaviors indicative of depression, such as immobility in the forced swimming test and social avoidance in stressed mice, effects that were reversed by inhibitors of mTOR and PI3K pathways.
- - The study suggests that DOP agonists work by enhancing excitatory activity in the medial prefrontal cortex through the PI3K-Akt-mTOR signaling pathway, particularly by reducing GABA release from specific interneurons.
Introduction: Corynebacterium species potentially develop high-level daptomycin resistance (HLDR) shortly after daptomycin (DAP) administration. We aimed to investigate the clinical and microbiological characteristics of HLDR Corynebacterium infections.
Methods: We first presented a clinical case accompanied by the results of a comprehensive genetic analysis of the isolate, and then performed a systematic scoping review.
Chemogenetic activation of hepatic G signaling ameliorates hepatic steatosis and obesity.
Biochim Biophys Acta Mol Basis Dis
February 2025
Article Synopsis
- The study investigates the role of G signaling in hepatic steatosis and obesity, highlighting a gap in targeted treatments for nonalcoholic fatty liver disease (NAFLD).
- Mice with liver-specific G-coupled designer GPCR showed that activating G signaling can reduce hepatic steatosis progression and promote fat oxidation, even under high-fat diets.
- The research suggests that G signaling activation has potential therapeutic benefits for preventing liver fat accumulation and obesity, paving the way for future drug development targeting liver GPCRs.
Article Synopsis
- The study investigates carbapenemase-producing Enterobacterales (CPE) at Okayama University Hospital over 5 years (2013-2018), revealing a variety of CPE isolates with different phenotypic and genetic characteristics.
- Eight CPE isolates were identified, mainly carrying blaIMP-1 and blaIMP-6 genes, with significant diversity in bacterial species and carbapenem susceptibility patterns.
- The findings highlight the importance of continuous genetic surveillance and customized infection control measures to combat the spread of CPE.