Super-resolution deep learning reconstruction for improved quality of myocardial CT late enhancement.

Purpose: Myocardial computed tomography (CT) late enhancement (LE) allows assessment of myocardial scarring. Super-resolution deep learning image reconstruction (SR-DLR) trained on data acquired from ultra-high-resolution CT may improve image quality for CT-LE. Therefore, this study investigated image noise and image quality with SR-DLR compared with conventional DLR (C-DLR) and hybrid iterative reconstruction (hybrid IR).

Propagation of goose primordial germ cells in vitro relies on FGF and BMP signalling pathways.

Mitotically active embryonic reproductive cells, the primordial germ cells (PGCs), are an ideal cell type for cryopreserving functional reproductive cells for avian species. Their low number in the avian embryo, however, renders cryopreservation and germline transmission methodologies difficult. Here, we develop a culture medium for the long-term in vitro culture of PGCs from the goose, Anser anser domesticus.

Targeting glioma with heteroaromatic alkaloids: A review of potential therapeutics.

Glioblastoma multiforme (GBM), classified as a grade IV astrocytoma, is the most aggressive and deadly form of glioma, characterized by rapid progression, extensive genetic heterogeneity, and resistance to conventional therapies. Despite advancements in surgical techniques, radiation therapy, and the frontline chemotherapeutic agent temozolomide, the prognosis for GBM patients remains poor, with a median survival of 15 months and a 5-year survival rate of approximately 7 %. The absence of effective long-term treatments underscores the urgent, unmet clinical need for novel therapeutic strategies to improve patient outcomes.

Association Between the Effectiveness and Magnitude of Foot Microcirculation Assessed by Radionuclide Angiography and One Year Limb Outcomes in Patients with Chronic Limb Threatening Ischaemia.

Objective: Microcirculation focused evaluations may provide physiological insights that complement those of the established clinical criteria for patients with chronic limb threatening ischaemia (CLTI), since complex treatments are needed in this high risk population. However, current methods for quantitatively assessing foot microcirculation are limited. Thus, in this study, the aim was to demonstrate a proof of concept non-invasive method with novel parameters for assessing foot microcirculation.

MR Imaging Indices for Brain Interstitial Fluid Dynamics and the Effects of Orexin Antagonists on Sleep.

Purpose: The purpose of this study was to assess the extent to which improvement in sleep with lemborexant contributed to changes in interstitial fluid dynamics.

Methods: The 3 methods including diffusion tensor image analysis along the perivascular space (DTI-ALPS), dynamic contrast-enhanced method to assess tissue vascular permeability (Ktrans), and choroid plexus volume (CPV) were used. Correlations between these imaging indices and sleep parameters (latency to persistent sleep [LPS], wake after sleep onset [WASO], total sleep time [TST], and sleep efficiency [SE]) were evaluated using Pearson correlation analysis.