The purpose of this case series was to evaluate the presence of low Energy Availability (EA) and its impact on components of Relative Energy Deficiency in Sport (RED-S) in a population of female collegiate runners. Seven female NCAA Division I athletes (age: 22.3 ± 1.
View Article and Find Full Text PDFThe biomanufacturing industry has now the opportunity to upgrade its production processes to be in harmony with the latest industrial revolution. Technology creates capabilities that enable smart manufacturing while still complying with unfolding regulations. However, many biomanufacturing companies, especially in the biopharma sector, still have a long way to go to fully benefit from smart manufacturing as they first need to transition their current operations to an information-driven future.
View Article and Find Full Text PDFMonitoring and control of fermentation processes remain a crucial challenge for both laboratory and industrial-scale experiments. Reliable identification and quantification of the key process parameters in on-line mode allow operation of the fermentation at optimal reactor efficiency, maximizing productivity while minimizing waste. However, state-of-the-art fermentation on-line monitoring is still limited to a number of standard measurements such as pH, temperature and dissolved oxygen, as well as off-gas analysis as an advanced possibility.
View Article and Find Full Text PDFFermentation processes are still compromised by a lack of monitoring strategies providing integrated process data online, ensuring process understanding, control, and thus, optimal reactor efficiency. The crucial demand for online monitoring strategies, not only encouraged by the PAT initiative but also motivated by modern paradigms such as circular economy and sustainability, has driven research and industry to provide "next-generation process technology": in other words, technology tailored toward industrial needs. Mid-infrared (MIR) spectroscopy as such is superior to near-infrared (NIR) spectroscopy since it provides significantly enhanced selectivity.
View Article and Find Full Text PDFReal-time monitoring of bioprocesses plays a key-role in modern industries, providing new information on full-scale production, thus enabling control of the process and allowing it to run at optimal conditions while minimizing waste. Monitoring of phosphates and ammonium in fermentation processes has a twofold interest: they are important nutrients for living organisms while at the same time constituting environmental nutrient pollutants, for which unnecessary use and disposal must be avoided. In this report, the possibility of simultaneous analysis of phosphates and ammonium in fermentations was verified using spectroscopy-based methods combined with chemometrics to construct calibration models.
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