Publications by authors named "K I Odarenko"
Soloxolone amides are semisynthetic triterpenoids that can cross the blood-brain barrier and inhibit glioblastoma growth both and . Here we investigate the impact of these compounds on processes associated with glioblastoma invasiveness and therapy resistance. Screening of soloxolone amides against glioblastoma cells revealed the ability of compound (soloxolone -methylanilide) to inhibit transforming growth factor-beta 1 (TGF-β1)-induced glial-mesenchymal transition Compound inhibited morphological changes, wound healing, transwell migration, and expression of mesenchymal markers (N-cadherin, fibronectin, Slug) in TGF-β1-induced U87 and U118 glioblastoma cells, while restoring their adhesiveness.
View Article and Find Full Text PDFLung cancer is the leading cause of cancer-related death worldwide. Its high mortality is partly due to chronic inflammation that accompanies the disease and stimulates cancer progression. In this review, we analyzed recent studies and highlighted the role of the epithelial-mesenchymal transition (EMT) as a link between inflammation and lung cancer.
View Article and Find Full Text PDFArticle Synopsis
- - Despite cancer-causing effects of leptin in some cancers, its role in neuroblastoma was not well-studied until now, showing higher levels correlate with worse outcomes and reduced patient survival.
- - Leptin treatment in mouse neuroblastoma cells led to increased cell growth and movement while decreasing their ability to stick together, making them more aggressive.
- - Soloxolone methyl (SM) was found to counteract leptin's effects by stopping cell growth and restoring adhesion properties, while also inhibiting key survival pathways in cancer cells, suggesting a potential therapeutic strategy.
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by uncontrollable diffusive growth, resistance to chemo- and radiotherapy, and a high recurrence rate leading to a low survival rate of patients with GBM. Due to a large number of signaling pathways regulating GBM pathogenesis, one of the promising directions is development of novel anti-glioblastoma compounds based on natural metabolites capable of affecting multiple targets. Here, we investigated the antitumor potential of the semisynthetic triterpenoid soloxolone tryptamide (STA) against human glioblastoma U87 cells.
View Article and Find Full Text PDFProtective effect of soloxolone derivatives in carrageenan- and LPS-driven acute inflammation: Pharmacological profiling and their effects on key inflammation-related processes.
Biomed Pharmacother
March 2023
Article Synopsis
- - The study investigated three triterpenoids (SM, S, and SAO) for their anti-inflammatory effects in mice, showing they can effectively reduce inflammation caused by carrageenan and LPS.
- - The compounds were seen to have therapeutic effects similar to standard anti-inflammatory drugs like indomethacin and dexamethasone, especially showing improved effectiveness against carrageenan-induced inflammation when modified.
- - Additionally, these compounds inhibited important immune processes, preventing cell damage and reducing inflammation-related cell death, suggesting their potential as new multi-targeted anti-inflammatory drugs.