Towards optimized methodological parameters for maximizing the behavioral effects of transcranial direct current stimulation.

Introduction: Transcranial direct current stimulation (tDCS) administers low-intensity direct current electrical stimulation to brain regions via electrodes arranged on the surface of the scalp. The core promise of tDCS is its ability to modulate brain activity and affect performance on diverse cognitive functions (affording inferences regarding regional brain activity and behavior), but the optimal methodological parameters for maximizing behavioral effects remain to be elucidated. Here we sought to examine the effects of 10 stimulation and experimental design factors across a series of five cognitive domains: motor performance, visual search, working memory, vigilance, and response inhibition.

Translation, cross-cultural adaptation, and validation of the Duke Activity Status Index (DASI) to Sinhala language.

Background: Duke Activity Status Index (DASI) is a widely used tool to assess functional capacity among patients, but there is no Sinhala version validated for patients in Sri Lanka. This study aimed to cross-culturally adapt and test the validity and reliability of the Sinhala version of DASI (DASI-S).

Methods: The translation and cross-cultural adaptation of the DASI questionnaire were conducted following the standard guidelines.

Eco-friendly treatment of copper smelting flue dust for recovering multiple heavy metals with economic and environmental benefits.

Handling flue dust in an environmentally friendly manner has become an urgent task for pollution prevention in the copper industry. Here, driven by the low-carbon notion, we report a process that enables the selective retrieval of multiple metals (As, Cu, Pb, Zn, and Bi) from copper smelting flue dust (CSFD). This process employed low-temperature roasting to separate arsenic from heavy metals, thereby eliminating the tedious separation steps required by existing processes.

Docetaxel-Loaded Methoxy poly(ethylene glycol)-poly (L-lactic Acid) Nanoparticles for Breast Cancer: Synthesis, Characterization, Method Validation, and Cytotoxicity.

This study aimed to synthesize and characterize DTX-mPEG-PLA-NPs along with the development and validation of a simple, accurate, and reproducible method for the determination and quantification of DTX in mPEG-PLA-NPs. The prepared NPs were characterized using AFM, DLS, zetasizer, and drug release kinetic profiling. The RP-HPLC assay was developed for DTX detection.

Development of New Azomethine Metal Chelates Derived from Isatin: DFT and Pharmaceutical Studies.

Through the condensation of isatin (indoline-2, 3-dione) and aniline in a 1:1 ratio, a Schiff base ligand was synthesized and characterized via (H-NMR, mass, IR, UV-Vis) spectra. Elemental analyses, spectroscopy (H-NMR, mass, UV-Vis), magnetic susceptibility, molar conductivity, mass spectra, scanning electron microscope (SEM), and thermal analysis have all been used to characterize a series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) metal complexes derived from the titled ligand. The metal-to-ligand ratio is 1:1, according to the analytical data.