Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood.

Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk of Alzheimer disease, solid tumors, and other age-related diseases. We sought to gain a better understanding of genetic drivers and associated phenotypes of mLOY through analyses of whole-genome sequencing (WGS) of a large set of genetically diverse males from the Trans-Omics for Precision Medicine (TOPMed) program.

Whole genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia.

In studies of individuals of primarily European genetic ancestry, common and low-frequency variants and rare coding variants have been found to be associated with the risk of bipolar disorder (BD) and schizophrenia (SZ). However, less is known for individuals of other genetic ancestries or the role of rare non-coding variants in BD and SZ risk. We performed whole genome sequencing of African American individuals: 1,598 with BD, 3,295 with SZ, and 2,651 unaffected controls (InPSYght study).

Developmental normative data for the Balance Tracking System modified Clinical Test of Sensory Integration and Balance protocol.

A growing number of practitioners are implementing the Balance Tracking System (BTrackS) modified Clinical Test of Sensory Integration and Balance (mCTSIB) to evaluate the sensory sources of balance feedback used to maintain upright standing. The aim of the current study was to expand existing BTrackS mCTSIB normative databases on adults to include reference values from developmental age groups. Participants included children (age range = 5-8 years; n = 212), adolescents (age range = 9-12 years; n = 103), teenagers (age range = 13-17 years; n = 152), and young adults (age range = 18-29 years; n = 779).

Session Introduction: Overcoming health disparities in precision medicine: Intersectional approaches in precision medicine.

The following sections are included: Overview, Advancing multi-ancestry genetic research, Integrating social determinants of health to enhance genetic risk models, Methods to detect and mitigate disparities, Addressing Disparities in Adverse Drug Reactions, Conclusion, Acknowledgments,References.