Publications by authors named "K I Ayeni"
Article Synopsis
- Mycotoxins, which are harmful fungal toxins, can negatively affect pregnant women and their babies, but there's limited information about their exposure in the US, particularly among pregnant women.
- This study analyzed mycotoxin exposure in a group of 50 women during pregnancy by testing samples of their serum and urine at various stages using advanced liquid chromatography techniques.
- Results indicated the presence of several mycotoxins, with notable detection rates for ochratoxin A and deoxynivalenol, showing some women exceeded recommended daily intake levels for these toxins.
Complementary foods (CFs) commonly consumed by infants and young children (IYC) in sub-Saharan Africa (SSA) are processed using either single or multi-grain ingredients through simple technologies such as fermentation, malting and roasting. Interestingly, CFs (e.g.
View Article and Find Full Text PDFEarly-life exposure to natural and synthetic chemicals can impact acute and chronic health conditions. Here, a suspect screening workflow anchored on high-resolution mass spectrometry was applied to elucidate xenobiotics in breast milk and matching stool samples collected from Nigerian mother-infant pairs (n = 11) at three time points. Potential correlations between xenobiotic exposure and the developing gut microbiome, as determined by 16S rRNA gene amplicon sequencing, were subsequently explored.
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- Researchers developed a targeted LC-MS/MS assay to study 86 different polyphenol analytes in human breast milk, aiming to better understand their impact on infant health during breastfeeding.
- The assay showed that nearly 70% of the polyphenols met strict validation criteria for quantitative assessment, providing valuable insights, even for those that didn't completely meet all criteria.
- A proof-of-principle study analyzed samples from twelve Nigerian mothers, detecting 50 polyphenol analytes, including phenolic acids and phase II metabolites, suggesting these compounds may positively influence microbiome development and overall infant health.
Mycotoxins are toxic chemicals that adversely affect human health. Here, we assessed the influence of mycotoxin exposure on the longitudinal development of early life intestinal microbiota of Nigerian neonates and infants (NIs). Human biomonitoring assays based on liquid chromatography tandem mass spectrometry were applied to quantify mycotoxins in breast milk ( = 68) consumed by the NIs, their stool ( = 82), and urine samples ( = 15), which were collected longitudinally from month 1-18 postdelivery.
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