Characterization for the Similarity Assessment Between the Proposed Biosimilar SB17 and Ustekinumab Reference Product Using State-of-the-Art Analytical Methods.

Background: SB17 is being developed as a biosimilar to ustekinumab reference product (RP), a human monoclonal antibody (IgG1 kappa immunoglobulin) that binds to the common p40 subunit of cytokines interleukin (IL)-23 and IL-12. Binding to this subunit prevents interaction with their receptor, resulting in modulation in the immune system responses that play a key role in inflammatory disease.

Objective: The objective of this study was to demonstrate structural, physicochemical, and biological similarity between ustekinumab RP and SB17 using various state-of-the-art analytical methods.

Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital.

Next-generation sequencing (NGS) cancer profiling has gained traction in routine clinical practice in South Korea. Here, we evaluated the use of NGS testing and genomically-matched therapies for patients with advanced solid tumors in a real-world clinical practice. We analyzed results from NGS cancer panel tests (SNUBH pan-cancer version 2) ordered from June 2019 to June 2020.

The Role of A Beautiful Appearance in the Redemption of Female Ghosts.

The aim of this study is to analyze the role played by the appearance of female ghosts in their redemption. In the literature on ghosts, entries on female ghosts highlight their "beautiful appearance": Arang (Korean), Otsuyu (Japanese), The White Lady (Europe), Nie Xiaoqian (Chinese), and Maria Makiling (Filipino). Ghosts are women who died tragically, leaving behind unfulfilled desires-particularly those related to romantic or societal expectations such as marriage, love, and motherhood.

An integrative approach to generating explainable safety assessment scenarios for autonomous vehicles based on Vision Transformer and SHAP.

Automated Vehicles (AVs) are on the cusp of commercialization, prompting global governments to organize the forthcoming mobility phase. However, the advancement of technology alone cannot guarantee the successful commercialization of AVs without insights into the accidents on the read roads where Human-driven Vehicles (HV) coexist. To address such an issue, The New Car Assessment Program (NCAP) is currently in progress, and scenario-based approaches have been spotlighted.

Recommendation for the use of respiratory syncytial virus vaccines.

Respiratory syncytial virus (RSV) is the most common pathogen for young children hospitalized with bronchiolitis and pneumonia. Most infections occur below 1 year of age. RSV is also a significant viral pathogen for adults with respiratory tract infection.