Publications by authors named "K Hug"
Article Synopsis
- Balloon-expandable valves (BEVs) and self-expanding valves (SEVs) are compared for their effects on patients with Sievers type 1 bicuspid aortic valve (BAV) stenosis undergoing transcatheter aortic valve replacement.
- The analysis, based on a registry of 955 patients, found no significant difference in midterm major adverse events or technical success between BEVs and SEVs after adjusting for baseline differences.
- However, BEVs had lower risks of new permanent pacemaker implantation and moderate or greater paravalvular regurgitation, but a higher risk of severe patient-prosthesis mismatch compared to SEVs.
Article Synopsis
- Many pathogenic bacteria possess plasmids that encode virulence factors, essential for their ability to infect and colonize hosts, but the regulation of these plasmids is not well understood.
- The study focuses on the type III secretion system (T3SS), crucial for human pathogenic bacteria, and reveals that its expression is influenced by the plasmid copy number, which increases with temperature, aiding in bacterial virulence.
- The chromosomal gene encoding polyadenylase PAP I is vital for controlling plasmid copy number, maintaining plasmid stability, and enhancing antibiotic resistance, highlighting its role in the regulation of virulence and antimicrobial resistance plasmids in bacteria.
Article Synopsis
- Transcatheter aortic valve replacement (TAVR) for patients with bicuspid aortic valve (BAV) stenosis can lead to complications like paravalvular regurgitation (PVR), which is the leakage of blood around the valve.
- A study involving 946 patients aimed to understand how often PVR occurs after TAVR, what factors predict it, and its impact on patient outcomes, finding that 44.7% experienced some level of PVR.
- Moderate or severe PVR was linked to higher risks of major adverse events (MAEs) like death or hospitalization, highlighting the importance of careful monitoring and management in these patients.
Article Synopsis
- Modified balloon angioplasty (MB) and intravascular lithotripsy (IVL) are treatments for in-stent restenosis (ISR), but IVL is currently used off-label in this scenario.
- A study involving 117 patients (36 treated with IVL and 81 with MB) found that IVL resulted in significantly lower residual stenosis compared to MB (2.8% vs. 21.0%).
- Despite the differences in stenosis rates, long-term follow-up showed no significant differences in cardiac death, acute myocardial infarction, or target lesion revascularization between the two treatment groups.
Retention of circulating lipoproteins by their interaction with extracellular matrix molecules has been suggested as an underlying mechanism for atherosclerosis. We investigated the role of glypican-4 (GPC4), a heparan sulfate (HS) proteoglycan, in the development of endothelial dysfunction and plaque progression; Expression of GPC4 and HS was investigated in human umbilical vein/artery endothelial cells (HUVECs/HUAECs) using flow cytometry, qPCR, and immunofluorescent staining. Leukocyte adhesion was determined in HUVECs in bifurcation chamber slides under dynamic flow.
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