Publications by authors named "K Huebel"
: ABO-incompatible live-donor kidney transplantation (ABOi-LDKT) has become an established treatment for end-stage renal disease. Non-inferiority in the long-term graft function compared to ABO-compatible live-donor kidney transplantations (ABOc-LDKTs) has been shown. However, the assumed burden due to complications owing to increased immunosuppression inherent to ABOi-LDKTs has not yet been quantified.
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- Mantle cell lymphoma (MCL) is a subtype of B-cell lymphoma, and while rituximab is commonly used in treatment, its effectiveness on overall survival in first-line therapy has been debated.
- A pooled analysis of two trials, involving 385 untreated adult MCL patients, revealed that adding rituximab to the standard CHOP regimen improved failure-free survival (FFS) and overall survival (OS) significantly after a median follow-up of 13.4 years.
- Results indicated that the combination treatment not only increased FFS and OS but also showed consistent effectiveness across various MCL risk groups, supporting the use of R-CHOP as the standard of care.
Purpose: The lateral geniculate nucleus (LGN) is an essential nucleus of the visual pathway, occupying a small volume (60-160 mm) among the other thalamic nuclei. The reported LGN volumes vary greatly across studies due to technical limitations and due to methodological differences of volume assessment. Yet, structural and anatomical alterations in ophthalmologic and neurodegenerative pathologies can only be revealed by a precise and reliable LGN representation.
View Article and Find Full Text PDFThis study aimed to characterize the role of the neuropeptide calcitonin gene-related peptide (CGRP) in the development of mechanically induced visceral hyperalgesia. Tonic colorectal distension (CRD) was performed in fasted, conscious male Sprague-Dawley rats. The visceromotor reflex associated with noxious CRD was determined as the number of contractions during each of two consecutive tonic distensions (10 min at 60 mmHg), which were separated by a series of phasic distensions (repeated 15-s distensions to 80 mmHg at 30-s intervals).
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