Publications by authors named "K Horny"
Article Synopsis
- Whole Exome Sequencing (WES) is a powerful tool in cancer diagnostics that allows for comprehensive analysis of genes, improving the detection of complex biomarkers compared to traditional panel-based methods.
- A study analyzing tissue specimens across 21 NGS centers showed that, although there was a 76% agreement in somatic variant calling, refining filtering criteria improved this to 88%, highlighting the importance of filter settings in variant detection.
- The reliability of detecting specific genomic changes (like CNAs and complex biomarkers) varied among labs, emphasizing the need for improved bioinformatics processes and collaborative testing to minimize discrepancies in future analyses.
Article Synopsis
- Mycosis fungoides (MF) is a common type of skin cancer that makes it hard to tell harmful T cells from normal ones.
- Researchers used single-cell RNA and T-cell receptor sequencing on skin samples from 12 MF patients, analyzing 18,630 T cells from 9 of them to distinguish between malignant and reactive cells.
- The study found unique gene signatures in malignant T cells that could help differentiate them from reactive T cells, revealing significant variations in cell characteristics among patients.
Background: Oral squamous cell carcinoma (OSCC), an HPV-negative head and neck cancer, frequently metastasizes to the regional lymph nodes but only occasionally beyond. Initial phases of metastasis are associated with an epithelial-mesenchymal transition (EMT), while the consolidation phase is associated with mesenchymal-epithelial transition (MET). This dynamic is referred to as epithelial-mesenchymal plasticity (EMP).
View Article and Find Full Text PDFBackground: Sézary Syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphomas (CTCL). In SS patients, malignant T cells are circulating through the blood and cause erythroderma.
Objective: To compare the transcriptome of single cells in blood and skin samples from a patient with advanced SS.