Publications by authors named "K Hewlett"
Article Synopsis
- VREfm is a significant healthcare-acquired pathogen that can lead to serious bloodstream infections, and previous studies focused on its presence within healthcare facilities.
- A study involving 710 clinical isolates collected from 2017-2022 revealed that nearly half of the isolates formed genetically similar clusters, indicating a high rate of transmission in the hospital.
- Comparison with a large database of VREfm genomes over 20 years showed a notable shift in the populations of VREfm within hospitals, suggesting that antimicrobial peptides like bacteriocin T8 might play a crucial role in the emergence and persistence of these strains.
Article Synopsis
- Two important bacteria, known for their impact on public health, colonize the human gut and interact in ways that can worsen disease outcomes.
- Infections caused by one of the bacteria lead to the release of nutrients, particularly heme, which the other bacteria can utilize to thrive and grow more effectively in the gastrointestinal tract.
- Gaining insight into how these bacteria interact may help develop new treatments for Clostridium difficile infections (CDI).
Antibiotic-induced gut dysbiosis (AID) is a frequent and serious side effect of antibiotic use and mitigating this dysbiosis is a critical therapeutic target. We propose that the host diet can modulate the chemical environment of the gut resulting in changes to the structure and function of the microbiome during antibiotic treatment. Gut dysbiosis is typically characterized by increases in aerobic respiratory bacterial metabolism, redox potential, and abundance of Proteobacteria.
View Article and Find Full Text PDFThe microbiome is essential for host health, and perturbations resulting from antibiotic use can lead to dysbiosis and disease. Diet can be a powerful modulator of microbiome composition and function, with the potential to mitigate the negative effects of antibiotic use. Thus, it is necessary to study the impacts of diet and drug interactions on the gut microbiome.
View Article and Find Full Text PDFNon-nucleoside reverse transcriptase inhibitors (NNRTIs) inhibit reverse transcription and block the replication of HIV-1. Currently, NNRTIs are usually used as part of a three-drug combination given to patients as antiretroviral therapy. These combinations involve other classes of anti-HIV-1 drugs, commonly nucleoside reverse transcriptase inhibitors (NRTIs).
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