Publications by authors named "K Herlyn"
Article Synopsis
- Cystic fibrosis (CF) is linked to osteoporosis, with a study evaluating 64 adults revealing that 52% had low bone mineral density (BMD) and that factors like male sex, use of glucocorticoids, and previous fractures were common among those with low BMD.
- The study utilized dual-energy X-ray absorptiometry to measure BMD at baseline and after two years, along with assessments of body mass indices and lung function.
- Key findings indicated that greater fat-free mass and height are positively associated with BMD, while low lung function and higher fat mass lead to greater declines in BMD over time, emphasizing the need for monitoring bone health in CF patients.
Background: Improvements in clinical care have led to increased life expectancy in patients with cystic fibrosis (CF) over the past several decades. Whether these improvements have had significant effects on bone health in patients with CF is unclear.
Methods: This is a cross-sectional study comparing clinical characteristics and bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA) in adults with CF evaluated in 1995-1999 to age-, race-, and gender-matched patients with CF evaluated in 2011-2013 at the same center on calibrated DXA machines.
Article Synopsis
- This study aimed to explore the prevalence of ANCA-associated vasculitides (AAV) and giant cell arteritis (GCA) in northern Germany during 2006 and compare the findings to a previous study from 1994.
- Researchers identified patients through various sources, recording details like the type of vasculitis, demographics, and mortality in urban (Luebeck) and rural (Segeberg) populations.
- The results showed a significant increase in prevalence rates for both AAV and GCA since 1994, particularly in urban areas, suggesting that improved diagnosis and treatment options have positively impacted patient outcomes.
Objective: The aim of the study was to characterize the expression of TLR2, TLR4 and TLR9 in PMNs of patients with granulomatosis with polyangiitis (GPA) and to elucidate the role of these receptors in GPA with respect to neutrophil activation.
Methods: The expression of TLR2, TLR4 and TLR9 was determined on ex vivo PMNs in whole blood samples of GPA patients (n = 35) and healthy controls (HCs) (n = 24). Isolated PMNs were stimulated in vitro with TLR agonists and assessed for degranulation, membrane proteinase 3 (mPR3) expression, soluble l-selectin shedding and cytokine production (IL-8) in five GPA patients and five HCs.