Publications by authors named "K Herbert"
Article Synopsis
- This study looked at how early treatment helps babies with spinal muscular atrophy (SMA), a condition that affects muscles.
- Researchers checked the health of 66 babies treated within the first 6 weeks of life and found good results, like all babies being able to sit up on their own.
- However, some babies with a certain genetic marker (two SMN2 copies) had a harder time walking compared to those with more copies, showing that more studies are needed to improve their care.
IntroductionEvaluation of shunt for malfunction and blockage is a common neurosurgical clinical scenario in day-to-day paediatric neurosurgery practice. Parental concern for shunt malfunction is normally considered a reliable indication for undertaking further assessment of a child with a shunt. Accuracy of parental diagnosis of shunt malfunction likely is dependent on combination of parental knowledge and patient symptomatology and familiarity of symptoms in relation to previous shunt malfunction symptoms.
View Article and Find Full Text PDFThe ability of cells to organize into tissues with proper structure and function requires the effective coordination of proliferation, migration, polarization, and differentiation across length scales. Skeletal muscle is innately anisotropic; however, few biomaterials can emulate mechanical anisotropy to determine its influence on tissue patterning without introducing confounding topography. Here, we demonstrate that substrate stiffness anisotropy coordinates contractility-driven collective cellular dynamics resulting in C2C12 myotube alignment over millimeter-scale distances.
View Article and Find Full Text PDFObjectives: To examine children and young people's (CYP), caregivers' and healthcare professionals' (HCPs) views or experiences of facilitators and barriers to CYP access to UK primary care services to better understand healthcare inequity. To explore differences across CYP subpopulations with greater health needs from deprived areas, identifying as ethnic minorities, with experiences of state care, special educational needs or disabilities, chronic conditions or mental health problems.
Design: Scoping review.