Publications by authors named "K Heintze"
Effects of food on pharmacokinetics of immediate release oral formulations.
Br J Clin Pharmacol
November 2015
Codeine Ultra-rapid Metabolizers: Age Appears to be a Key Factor in Adverse Effects of Codeine.
Drug Res (Stuttg)
December 2015
Codeine is widely used as an analgesic drug. Taking into account the high consumption of codeine, only few fatal adverse events have been published. A number of reports, where neonates and children showed serious or fatal adverse reactions, led to a restriction of the use of codeine in this patient group.
View Article and Find Full Text PDFThe case of drug causation of childhood asthma: antibiotics and paracetamol.
Eur J Clin Pharmacol
June 2013
Article Synopsis
- The rising rates of bronchial asthma have sparked global research into its causes, with early childhood use of antibiotics and paracetamol being highlighted as potential factors, although confounding factors may play a larger role in these associations.!* -
- A systematic review identified 64 studies, showing that many lacked controls for the reasons antibiotics or paracetamol were prescribed, which clouded their results and links to asthma.!* -
- The evidence suggests that the supposed link between antibiotics, paracetamol, and childhood asthma may be biased, leading to the conclusion that necessary antibiotics should not be withheld from children, nor should paracetamol be avoided for pain and fever relief.!*
BACKGROUND: The aim of this article was to evaluate the prognostic value of the MammaPrint(TM) signature in women $$ 60 years with invasive breast cancer. PATIENTS AND METHODS: 60 female patients were included in this prospective study. Eligibility criteria included: pT1c-3, pN0-1a, grade 2/3, hormone receptor-positive and HER2-negative tumor.
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