Publications by authors named "K Heikinheimo"
Article Synopsis
- Odontogenic tumors (OGTs) are rare, and primary intraosseous carcinoma NOS (PIOC) is an even rarer subtype with a poor prognosis, characterized by unclear immunohistochemical features and pathogenesis.
- A histopathological study of a PIOC case in the left mandible revealed a transition from an odontogenic keratocyst to carcinoma, with signs of malignant behavior such as invasive growth and specific biomarker alterations.
- Immunohistochemical analysis indicated increased levels of certain proteins (ARL4C, YAP) in the tumor, activation of Wnt/β-catenin signaling, and suggested that varied intracellular signaling pathways might play a role in the disease's pathogenesis.
Article Synopsis
- Canine oral squamous cell carcinoma (COSCC) is a common and aggressive oral tumor in dogs, with a significant risk of metastasis at diagnosis.
- The typical treatment involves wide surgical excision, which can have a considerable impact on a dog's quality of life.
- Recent research shows that the MEK inhibitor trametinib, an FDA-approved drug for human cancers, effectively reduces COSCC cell growth and may lead to tumor regression in some canine patients, offering new hope for better treatment options.
Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. ACC is composed of myoepithelial and epithelial neoplastic cells which grow slowly and have a tendency for neural invasion. The long term prognosis is still relatively poor.
View Article and Find Full Text PDFBackground: Studies on the association between malocclusion and temporomandibular joint disorder (TMD) have reported conflicting results.
Objectives: To determine the impact of malocclusion and orthodontic treatment on symptoms of TMD.
Methods: At 12 years, 195 subjects fulfilled a questionnaire regarding TMD symptoms and participated in an oral examination including preparation of dental casts.
Ameloblastoma is a benign, locally invasive epithelial odontogenic neoplasm of the jaw. Treatment of choice is jaw resection, often resulting in significant morbidity. The aim of this study was to recapitulate ameloblastoma in a completely humanised 3D disease model containing ameloblastoma cells, osteoblasts and activated osteoclasts to investigate the RANKL pathway within the ameloblastoma stromal environment and its response to the RANKL antibody denosumab.
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