Publications by authors named "K Haurogne"
Article Synopsis
- - Diabetes is a significant public health issue influenced by genetic and environmental factors, with some models, like monogenic forms in mice, helping to understand the disease better.
- - A study involving NOD mice with a specific genetic mutation (Akt2 invalidation) showed that these mice developed severe hyperglycemia early on, particularly in males, without the influence of an autoimmune response.
- - The research found that the HYP mice exhibited hyperinsulinemia before hyperglycemia and had lower insulin levels in their pancreas compared to NOD mice, suggesting that failure of beta cells is a key factor in the development of diabetes.
Nowadays, most pigs are raised indoors, on intensive farms providing a poor environment. In these conditions, the risk of the occurrence of damaging behaviours is high, with dramatic consequences for animal health and welfare as well as economic losses for farmers. Early-life conditions may predispose individuals to develop damaging behaviours later in life.
View Article and Find Full Text PDFBackground: Multiple antigenic stimulations are crucial to immune system training during early post-natal life. These stimulations can be either due to commensals, which accounts for the acquisition and maintenance of tolerance, or to pathogens, which triggers immunity. In pig, only few works previously explored the influence of natural exposition to pathogens upon immune competence.
View Article and Find Full Text PDFA bioartificial pancreas (BAP) encapsulating high pancreatic islets concentration is a promising alternative for type 1 diabetes therapy. However, the main limitation of this approach is O supply, especially until graft neovascularization. Here, we described a methodology to design an optimal O-balanced BAP using statistical design of experiment (DoE).
View Article and Find Full Text PDFNonhypoalbuminemic Inflammatory Bowel Disease in Dogs as Disease Model.
Inflamm Bowel Dis
November 2021
Background: The incidence of inflammatory bowel disease (IBD) is increasing worldwide, emphasizing the need of relevant models, as dogs spontaneously affected by IBD may be, for better knowledge of the disease's physiopathology.
Methods: We studied 22 client-owned dogs suffering from IBD without protein loss and 14 control dogs. Biopsies were obtained from the duodenum, ileum, and colon.