Publications by authors named "K Hashii"
Aims: This study aimed to evaluate the long-term results of Japan Maternal Emergency Life-Saving (J-MELS) simulation training on obstetric healthcare providers, over a 12-month follow-up period.
Methods: A total of 273 trainees from 17 J-MELS Basic courses conducted between August 2021 and October 2023 were included. The trainees' responses to the pre- and post-tests, questionnaires, and self-reports on the usefulness of the J-MELS scenarios in actual clinical settings at 1, 6, and 12 months after the training were analyzed.
Here, we aimed to provide an overview of Japan Council for the Implementation of the Maternal Emergency Life-Saving System (J-CIMELS) and its simulation program, which has reduced maternal mortality due to direct causes in Japan. The Japan Association of Obstetricians and Gynecologists (JAOG), Japan Association of Obstetricians and Gynecologists, and Maternal Death Exploratory Committee (JMDEC) launched the Maternal Death Reporting Project in 2010. The project analyzed obstetricians' tendency to delay their initial response to sudden maternal deterioration.
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- MCCs (membrane-coordinated complexes) are specialized structures in yeast that contain various proteins, including the core protein Pil1, which helps maintain their function.
- Research on mutant strains lacking Pil1 and other proteins showed that the Sur7 and Nce102 families of six-tetraspan membrane proteins play distinct roles in dealing with stress and contributing to normal assembly of MCCs.
- The study revealed that the stress sensitivity in specific mutants is linked to an overactive signaling pathway involving TOR kinase complex 2 (TORC2), and that Pil1 and 6-Tsp work together to regulate this signaling during stress responses.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFBacterial pathogens possess complex type III effector (T3E) repertoires that are translocated inside the host cells to cause disease. However, only a minor proportion of these effectors have been assigned a function. Here, we show that the T3E AWR5 from the phytopathogen Ralstonia solanacearum is an inhibitor of TOR, a central regulator in eukaryotes that controls the switch between cell growth and stress responses in response to nutrient availability.
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