Modulation of circulating IGF-I and IGFBP-3 levels by hormonal regulators of energy homeostasis in obese children.

Unlabelled: Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are key factors in the control of somatic growth. Recent work revealed a critical role for the transcription factor STAT5b in GH stimulated IGF-I gene expression. In obesity, the normal regulation of the GH/IGF-I axis is disturbed, with normal levels of circulating IGF-I despite blunted GH secretion.

Pancreatic polypeptide in obese children before and after weight loss.

Objective: Little is known concerning pancreatic polypeptide (PP) in weight loss and in childhood obesity.

Methods: Fasting PP, leptin and insulin concentrations were determined in 38 obese children and compared with 35 lean children of the same age, gender and pubertal stage. Furthermore, changes of PP concentrations over a 1-year period were analyzed in the obese children participating in a weight loss intervention program.

Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss.

Context: The gut hormone peptide YY(3-36) (PYY) reduces food intake via hypothalamic Y2 receptors in the brain. There is not much known about PYY in obese children.

Objective: The objective of this study was to investigate the role of PYY in the metabolic changes in obese children and its change during weight loss.

Obesity in patients with craniopharyngioma: assessment of food intake and movement counts indicating physical activity.

Patients with childhood-onset craniopharyngioma (CP) often suffer from obesity. We evaluated two important etiological factors of obesity development, energy intake and physical activity. Energy intake was supposed to be high due to a disturbed hypothalamic regulation of appetite.

Obesity after childhood craniopharyngioma--German multicenter study on pre-operative risk factors and quality of life.

Background: Craniopharyngiomas are tumorous embryogenic malformations. As the survival rate after craniopharyngioma is high (92 %), prognosis and quality of life (QoL) in survivors mainly depend on adverse late effects such as obesity.

Patients And Methods: We analyzed 214 children and adolescents with craniopharyngioma.