Publications by authors named "K Harkness"
Article Synopsis
- * The research involved examining the relationship between MDD, childhood maltreatment (CM), and eCB levels in blood plasma from 91 adults with MDD and 62 healthy participants.
- * Findings indicate that while MDD is associated with higher eCB levels, the relationship between CM and hippocampal volume shows that only lower levels of one eCB (AEA) are linked to reduced hippocampal volume, highlighting the complex role of eCBs in stress and depression.
Background: A critical challenge in the study and management of major depressive disorder (MDD) is predicting relapse. We examined the temporal correlation/coupling between depression and anxiety (called Depression-Anxiety Coupling Strength, DACS) as a predictor of relapse in patients with MDD.
Methods: We followed 97 patients with remitted MDD for an average of 394 days.
Article Synopsis
- The CARE pilot trial is testing if surgery or medical treatment is better for people with a brain condition called cerebral cavernous malformation.
- Researchers faced challenges recruiting enough people for the trial, so they used a special method called the QuinteT Recruitment Intervention to improve the process.
- They found some problems that made it hard to recruit participants, like disagreements among doctors, but also discovered some doctors were willing to offer surgery, which helped get more people involved.
Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.
Biol Psychiatry Cogn Neurosci Neuroimaging
August 2024
Article Synopsis
- - The study investigates how major depressive disorder (MDD) affects brain structure and cognitive function, particularly looking at how these changes relate to normal brain development and aging in adolescents and adults.
- - Researchers analyzed brain data from 304 participants with MDD and 236 without, finding that individuals with MDD had lower brain centile scores, indicating atypical brain aging, and those scores were linked to working memory only in the control group.
- - The findings suggest that MDD is associated with unusual brain development and aging, but severity of depression and childhood maltreatment did not significantly influence brain measurements or treatment responses.
A common conjecture is that social success relies on "theory of mind"-the everyday skill of imputing mental states to others. We test the hypothesis that individuals with stronger theory of mind skills and motivation garner more positive first impressions because of how they interact with others. Participants included 334 young adults who were paired with a peer for a first-time meeting.
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