Publications by authors named "K Harano"
Background: Frailty increases the risk of needing nursing care and significantly affects the life and functional prognosis of older individuals. Early detection and tailored interventions are crucial for maintaining and enhancing their life functions. Recognizing distinct clinical phenotypes is essential for devising appropriate interventions.
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- The study aimed to explore the connection between the gut microbiome and the effectiveness of PARP inhibitors in treating ovarian cancer.
- Researchers analyzed fecal samples and blood for circulating tumor DNA from ovarian cancer patients on PARP inhibitor therapy, comparing microbiome composition and progression-free survival (PFS) between mutation-positive and mutation-negative patients.
- Findings indicated that in mutation-negative patients, higher levels of certain gut microbes correlated with longer PFS, while no specific gut bacteria showed this association for mutation-positive patients, suggesting different microbiome influences based on genetic mutation status.
Gold ultrathin nanorods (Au UNRs) are anisotropic nanostructures constructed by attaching gold nanoclusters in one dimension. Au UNRs exhibit localized surface plasmon resonance (LSPR) only in the longitudinal direction because their diameter is smaller than the Fermi wavelength of an electron (<2 nm). In this study, we found that the LSPR wavelength of oleylamine-stabilized Au UNRs is blue-shifted simply by mixing with Ag(I).
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- - A new assembly strategy for lyotropic chromonic liquid crystals (LCLCs) is introduced, leveraging π-π interactions and hydration of triethylene glycol (TEG) units to create stacking structures.
- - The meso-TEG-aryl-substituted porphyrin Au complex displayed different states and assembly modes based on the type of counteranions, forming a hexagonal columnar liquid crystal phase through charge-by-charge assembly.
- - Changes in LCLC behavior were noted in response to water levels, exhibiting both columnar and nematic phases, while magnetic fields could orient the columnar structures, which were confirmed through transmission electron microscopy (TEM).
Pentagon-Rich Caged Carbon Catalyst for the Oxygen Reduction Reaction in Acidic Electrolytes.
Angew Chem Int Ed Engl
December 2024
The interaction between electron spin and oxygen molecules in non-platinum catalysts, particularly carbon catalysts, significantly influences the catalytic performance of the oxygen reduction reaction (ORR). A promising approach to developing high-performance catalysts involves introducing five-membered ring structures with spin into graphitic carbons. In this study, we present the successful synthesis of cage-like cubic carbon catalysts enriched with pentagon structures using pentagon ring-containing C and a NaCl template.
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