Publications by authors named "K Harada"

Objectives: This study examined the association between polypharmacy and incident disability across the dietary variety score (DVS) strata among community-dwelling older adults.

Study Design: A prospective cohort study with community-dwelling adults aged ≥65 in Aichi, Japan.

Main Outcome Measures: Polypharmacy was defined as ≥5 concomitant prescription drugs per day.

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Objectives: With dementia prevalence rising globally among older adults, effective and scalable community-based interventions are urgently needed to reduce dementia onset. This study aimed to estimate the association of the going-out program with dementia onset in older adults.

Methods: A 5-year longitudinal observational study was employed.

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: the purpose of this study was to determine the contributions of mechanical, neural, morphological, and muscle quality factors on individual differences in the maximal ankle dorsiflexion range of motion (ROM). : A sample of 41 university students performed passive-dorsiflexion and morphological measurements. In the passive-dorsiflexion measurement, while the ankle was passively dorsiflexed, maximal dorsiflexion ROM was measured in addition to passive torque at a given angle and muscle-tendon junction (MTJ) displacement during the last 13° as mechanical factors, and stretch tolerance and muscle activation were measured as neural factors.

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Article Synopsis
  • Production of polychlorinated biphenyls (PCBs) has been banned since 2001, but health risks from exposure continue due to their metabolism by enzymes like CYP2B6, where gene polymorphisms may influence this process.
  • The study analyzed blood samples from 129 individuals to explore the relationship between specific CYP2B6 gene variants and levels of PCBs and their metabolites (OH-PCBs), finding variations in metabolism linked to different genotypes, particularly *1/*4 and *6/*6.
  • Results showed that the *1/*4 genotype was correlated with higher metabolite-to-parent compound ratios for certain PCBs, while the *6/*6 genotype showed the opposite effect, indicating complex interactions between genetic factors
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