Publications by authors named "K Hankenson"
Circulating monocytes infiltrate and coordinate immune responses in tissues surrounding implanted biomaterials and in other inflamed tissues. Here we show that immunometabolic cues in the biomaterial microenvironment govern the trafficking of immune cells, including neutrophils and monocytes, in a manner dependent on the chemokine receptor 2 (CCR2) and the C-X3-C motif chemokine receptor 1 (CX3CR1). This affects the composition and activation states of macrophage and dendritic cell populations, ultimately orchestrating the relative composition of pro-inflammatory, transitory and anti-inflammatory CCR2, CX3CR1 and CCR2 CX3CR1 immune cell populations.
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- * A promising alternative is a 3D porous scaffold made with fused filament fabrication (FFF) technology combined with silver-doped bioactive glass-ceramic particles, which shows potential for helping bone regeneration and has antibacterial properties.
- * The study evaluates the mechanical strength and antibacterial effectiveness of these scaffolds through various tests, demonstrating they are not only strong but also support cell growth, making them a viable solution for bone repair.
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- Genome-wide association studies (GWAS) have identified genetic links to autoimmune disorders but don't pinpoint causal variants or affected cell types; this research enhances understanding using advanced 3D genomic datasets.
- By integrating various genomic techniques, the study maps disease-associated variants to likely regulatory effector genes across 57 human cell types, revealing the complex genetic landscape of autoimmune diseases.
- The investigation identifies both shared and specific genetic pathways, leading to the exploration of squalene synthase as a potential drug target for controlling inflammation in conditions like multiple sclerosis and systemic lupus erythematosus.
Thrombospondin-1 (TSP1) is a matricellular protein associated with the regulation of cell migration through direct binding interactions with integrin proteins and by associating with other receptors known to regulate integrin function, including CD47 and CD36. We previously demonstrated that deletion of an epithelial TSP1 receptor, CD47, attenuates epithelial wound repair following intestinal mucosal injury. However, the mechanisms by which TSP1 contributes to intestinal mucosal repair remain poorly understood.
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- Recent genomic studies have found common genetic factors among alcohol, opioid, tobacco, and cannabis use disorders, though the specific genes and variants involved remain largely unknown.
- Researchers utilized advanced genomic datasets from various human cell types to investigate genomic regions related to these disorders, identifying significant heritability enrichments in specific cell types, especially in iPSC-derived cortical neurons and pancreatic beta cells.
- The study also uncovered important genetic connections between substance use disorders and Type 2 diabetes, suggesting that certain cell types play crucial roles in understanding the mechanisms behind these disorders.