tttrlib: modular software for integrating fluorescence spectroscopy, imaging, and molecular modeling.

Summary: We introduce software for reading, writing and processing fluorescence single-molecule and image spectroscopy data and developing analysis pipelines to unify various spectroscopic analysis tools. Our software can be used for processing multiple experiment types, e.g.

The Effect of Parental Weight and Genetics on the Body Mass Index of Very Low Birth Weight Infants as They Reach School Age.

Background: Prematurely born individuals are usually of low or normal weight in childhood; in adulthood, however, their probability of being overweight is twice that of persons born at full term. There is not yet any way to predict the weight development of premature babies.

Methods: A polygenic BMI score (BMI = body-mass index), calculated from the often very small individual effects of more than 2 million genetic variants, was recently described for adults.

Factorizing the Nephelauxetic Effect in Heteroleptic Molecular Rubies.

The interest in chromium(III) complexes has been renewed over the past decade for the design of efficient earth-abundant phosphorescent red-to-near-infrared spin-flip emitters and photocatalysts with long excited state lifetimes. In this context, we report the energy tuning of spin-flip excited states based on heteroleptic bis(tridentate) polypyridine chromium(III) complexes , namely, , and with the tridentate ligands L and L [X/Y = NMe, ,'-dimethyl-,'-dipyridin-2-ylpyridine-2,6-diamine; X/Y = CH, 2,6-bis(2-pyridylmethyl)pyridine and X/Y = S, 2,6-bis(pyridine-2-ylthio)pyridine]. The heteroleptic complexes are obtained via a novel synthetic approach toward the required intermediate labile triflato complexes Cr(L)(OTf) () from the respective chlorido precursors CrCl(L) () using trimethylsilyl trifluoromethanesulfonate.

Bridge editing of spin-flip emitters gives insight into excited state energies and dynamics.

Six-coordinate chromium(iii) complexes with high spin-flip (SF) photoluminescence quantum yields and lifetimes (molecular rubies) have attracted huge interest in the past years due to their applicability in sensing, photocatalysis or circularly polarised emission. However, clearcut design rules for high quantum yields and lifetimes are still lacking due to the multidimensional problem of the non-radiative decay of the SF states. Based on an isostructural series of complexes differing in the ligand backbone, we disentangle decisive structural and electronic features for SF excited state energies and non-radiative decays promoted by spin-orbit coupling, Jahn-Teller distortions and (thermally activated) multiphonon relaxation.