Publications by authors named "K HAACK"
Article Synopsis
- In three clinical trials involving 142 participants with Pompe disease, 17 were deemed suitable for home infusion of avalglucosidase alfa, receiving a total of 419 supervised infusions.
- The majority of participants with late-onset Pompe disease (LOPD) experienced non-serious adverse events, while those with infantile-onset Pompe disease (IOPD) did not report any adverse effects.
- The safety and adverse event rates during home infusion were comparable to those during clinic infusions, indicating that home administration is feasible and safe for stable patients with a prior good infusion history.
Article Synopsis
- There is a shared relationship between cardiovascular disease (CVD) and cancer, tied to common risk factors and biological pathways, which the study aims to explore across three diverse ethnic cohorts.
- The researchers employed a two-stage methodology involving epigenome-wide association studies and targeted analysis of differentially methylated positions (DMPs), unveiling significant epigenetic markers for CVD and cancer.
- The findings indicate interconnected biological pathways for CVD and cancer, suggesting potential for precision prevention strategies, including screening based on epigenetic signatures to identify at-risk patients in early diagnosis stages.
Background: Chronic kidney disease (CKD) is highly prevalent in Central America, and genetic factors may contribute to CKD risk. To understand the influences of genetic admixture on CKD susceptibility, we conducted an admixture mapping screening of CKD traits and risk factors in US Hispanic and Latino individuals from Central America country of origin.
Methods: We analyzed 1023 participants of HCHS/SOL (Hispanic Community Health Study/Study of Latinos) who reported 4 grandparents originating from the same Central America country.
Background: Although COVID-19 infection has been associated with a number of clinical and environmental risk factors, host genetic variation has also been associated with the incidence and morbidity of infection. The CRP gene codes for a critical component of the innate immune system and CRP variants have been reported associated with infectious disease and vaccination outcomes. We investigated possible associations between COVID-19 outcome and a limited number of candidate gene variants including rs1205.
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