Publications by authors named "K H Rademacher"

Article Synopsis
  • Parkinson's disease involves the death of dopamine neurons in the substantia nigra, but the mechanisms behind this degeneration are still unclear.
  • Researchers developed a chemogenetic mouse model to increase dopamine neuron activity, discovering that this led to changes in locomotor activity and early degeneration of specific neuron projections.
  • This study suggests that excessive neural activity contributes to the vulnerability and eventual death of dopamine neurons, providing new insights into the pathophysiology of Parkinson's disease.
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Purpose: This exploratory study described facilitators and barriers to reducing tobacco disparities in 2 small rural communities and identified ways to reduce tobacco use.

Methods: This was a descriptive design using qualitative methods. We created a resource database for 2 rural Kentucky counties, using a Culture of Health Framework.

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Radon exposure is the second leading cause of lung cancer, yet few Americans test their homes for radon, particularly in rural areas. The academic team and community partners engaged the public library systems in four rural counties to offer digital radon detectors for check-out as a means of increasing the public's access to free radon testing. The check-out procedures and instructional materials were created through an iterative process, and library personnel were educated on radon and home radon testing prior to launching the lending program.

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Neural activity is finely tuned to produce normal behaviors, and disruptions in activity likely occur early in the course of many neurodegenerative diseases. However, how neural activity is altered, and how these changes influence neurodegeneration is poorly understood. Here, we focus on evidence that the activity of dopamine neurons is altered in Parkinson's disease (PD), either as a compensatory response to degeneration or as a result of circuit dynamics or pathologic proteins, based on available human data and studies in animal models of PD.

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